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KMID : 0525720190240030173
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Journal of Chitin and Chitosan
2019 Volume.24 No. 3 p.173 ~ p.178
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Preparation and Evaluation of Shark Byproduct-Based Tissue Adhesive Containing Chitosan
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Kim Jin
Lee Chang-Moon
Lee Sook-Young
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Abstract
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In this study, shark byproduct (SB)-based tissue adhesive containing chitosan was prepared and evaluated for biomedical applications. The amino acid contents of SB extracts were over 67% (w/w). SB extracts-based tissue adhesives had less effect on L-929 cell viability than Dermabond®. The adhesive bonding strength results show that the strength of SB extract glue containing chitosan was higher than those of SB extract glue and Dermabond®. In the wound mouse model studies, the wounds treated with SB extract glue containing chitosan showed significantly rapid closure than other groups. Considering the results obtained, SB extracts-based tissue adhesives can have a potential in the field of wound healing.
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KEYWORD
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Shark byproduct, Tissue adhesive, Chitosan, Wound, Glue
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